The starting point of the project : a study carried out on the sulforaphane molecule in 1998!
At that time, the molecule was barely known in the scientific world and it was through a publication written by Professor Talalay of the University of Baltimore (USA) on the interests of sulforaphane and some of its mechanisms of action.
Fascinated by this new molecule with innovative properties, Ingood by Olga, the ingredients business unit of Olga , a family owned and independent food company for 3 generations based in Brittany, set up a project with the Brittany region to link the Bret on agricultural sector with the company. The aim of this project is to enhance regional products and stimulate innovation in the territory.
To this end, several varieties of cabbage were studied to determine which parts of the plant were the richest in sulforaphane . The research and development team quickly encountered the main problem caused by the sulforaphane molecule, its instability. This will result in 20 years of hard work, between studies and experiments, to make the molecule stable and available, a world first! First clinical observations in men’s health were made… This is how Prostaphane ® dietary supplement was born.
Isothiocyanates are produced by the enzymatic hydrolysis of glucosinolates found in cruciferous. There are more than 120 different glucosinolates. In broccoli, the predominant glucosinolate is glucoraphanin. Sulforaphane is naturally present in cruciferous in its precursor form – glucoraphanin (or “sulforaphane glucosinolate”).
Sulforaphane is naturally present in cruciferous in its precursor form – glucoraphanin (or “sulforaphane glucosinolate”).
The transformation of glucoraphanine into “free sulforaphane”, a bioactive molecule, requires the action of myrosinase (by hydrolysis). This mechanism occurs when the food is chopped, chewed or in contact with the intestinal bacterial flora. Nevertheless, myrosinase is heat-sensitive and is found in varying amounts in the plant and body.
The free form of sulforaphane is naturally unstable, highly reactive and degrades in a few days at room temperature.
Ingood by Olga succeed in stabilizing natural sulforaphane from broccoli seeds through an innovative encapsulation process.
Prostaphane® provides a free and stabilized form of sulforaphane ensuring constant dosage and optimal bioavailability.
Prostaphane® contains stable and active sulforaphane made from broccoli seed extract.
The seeds are harvested in Europe and are selected for their quality and sulforaphane content. They are GMO-free and are fully traceable from the crop to harvest.
All Prostaphane® manufacturing steps take place in France.
Once extracted, sulforaphane is stabilized by microencapsulation using a specific patented process and a powder concentrated in free and stabilized sulforaphane is obtained. This powder is finally integrated into a capsule to deliver 10 mg of sulforaphane per capsule.
The manufacture of Prostaphane® follows European regulations. The different steps of manufacturing are overseen by precise specifications. Checks are carried out throughout the process to ensure the quality and efficacy of the product. Audits are carried out regularly.
Traceability is assured from the production of the seed to the distribution of Prostaphane® boxes.
Most of them contain glucoraphanin, often under the misleading name “sulforaphane glucosinolate.” Glucoraphanin is an inactive molecule in this form.
There are several broccoli-based dietary supplements on the market.
Studies have shown that glucoraphanine only allows 10% bioavailability in sulforaphane.
Prostaphane® therefore offers a dietary supplement based on free sulforaphane, which, unlike other dietary supplements, allows an average bioavailability of 70% in sulforaphane.
Fahey et al., 2016, Stabilized Sulforaphane for Clinical Use: Phytochemical Delivery Efficiency. Mol. Nutr. Food Res. 0, 0, 2016, 1600766 DOI 10.1002/mnfr.201600766